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KMID : 0545120180280010165
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Journal of Microbiology and Biotechnology
2018 Volume.28 No. 1 p.165 ~ p.174
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Kaposi’s Sarcoma-Associated Herpesvirus Infection Modulates the Proliferation of Glioma Stem-Like Cells
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Jeon Hyung-Taek
Kang Yun-Hee
Yoo Seung-Min
Park Myung-Jin
Park Jong-Bae
Lee Seung-Hoon
Lee Myung-Shin
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Abstract
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Glioblastoma multiforme is the most lethal malignant brain tumor. Despite many intensive studies, the prognosis of glioblastoma multiforme is currently very poor, with a median overall survival duration of 14 months and 2-year survival rates of less than 10%. Although viral infections have been emphasized as potential cofactors, their influences on pathways that support glioblastoma progression are not known. Some previous studies indicated that human Kaposi’s sarcoma-associated herpesvirus (KSHV) was detected in healthy brains, and its microRNA was also detected in glioblastoma patients’ plasma. However, a direct link between KSHV infection and glioblastoma is currently not known. In this study, we infected glioblastoma cells and glioma stem-like cells (GSCs) with KSHV to establish an in vitro cell model for KSHV-infected glioblastoma cells and glioma stem-like cells in order to identify virologic outcomes that overlap with markers of aggressive disease. Latently KSHV-infected glioblastoma cells and GSCs were successfully established. Additionally, using these cell models, we found that KSHV infection modulates the proliferation of glioma stem-like cells.
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KEYWORD
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KSHV, HHV-8, glioblastoma, glioma stem-like cell, proliferation
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